A recent iScience study finds that the swine acute diarrhea syndrome coronavirus (SADS-CoV) promotes autophagy to maintain its replication inside host cells. Study: Swine Acute Diarrhea Syndrome Coronavirus Induces Autophagy to Promote Its Replication via the Akt/mTOR Pathway. The impact of autophagy on SADS-CoV replication was assessed by using rapamycin and 3-metyhlademine, which is a well-established inducer and inhibitor of autophagy, respectively. Study significanceThe current study describes a novel mechanism of SADS-C-V-induced autophagy, which is needed for viral replication and survival inside host cells. Moreover, the study identifies ITGA3 as a potential antiviral molecule that can prevent viral replication by inhibiting autophagy.
Klebsiella pneumoniae is the most well-known species in this family, which can cause pneumonia, meningitis, urinary tract infections and infections in the bloodstream. Klebsiella has overtaken MRSA as a health problem in the UK, with rates steadily increasing. From this, they found 3,482 isolates including 15 different species of Klebsiella, with half of the positive samples containing K. pneumoniae. Our research did not give any evidence of this, however, we did find resistant klebsiella in pets, such as cats and dogs. "Next we want to track how plasmids are transferred between strains, using a technique called long read sequencing."10 days ago News Medical
Many children live in homes with unused prescription drugs and expired medications, a new national poll suggests. Nearly half of parents say they have leftover prescription medication at home, according to the C.S. Four in five parents say they have disposed of over-the-counter medicine past the expiration date. Proper medication disposalMore than three in five parents say they are more careful about disposing leftover prescription medicine than over the counter medication. "Unused and expired medications are a public safety issue and pose health risks to children," Clark said.1 month ago News Medical
However, pacemaker implantation is an invasive procedure, and the lifesaving pacing the devices provide can be extremely painful. Currently available pacemakers work by implanting one or two leads, or points of contact, into the heart with hooks or screws. This precision will not only reduce pain for pacemaker patients by bypassing the heart's pain receptors, it will also allow the pacemaker to respond to different kinds of irregularities in more appropriate ways. "This technology could make life easier for patients all over the world, while also helping scientists and physicians learn more about how to monitor and treat the disease." Additionally, the device does not require a battery, which could save pacemaker patients from needing to replace the battery in their device every five to seven years, as is currently the norm.1 month ago News Medical
Study: Long COVID: An inevitable sequela of SARS-CoV-2 infection. One study observed that the prevalence of long COVID among children and adolescents was 25.24%, whereas the rate of long COVID was 29.19% for hospitalized patients. One meta-analysis observed anxiety and depression in 22% and 23% of long COVID patients, respectively. Based on currently available information, long COVID could develop in all COVID-19 patients, although severe patients are at an increased risk. Furthermore, long COVID could present with heterogeneous clinical manifestations, with vaccination potentially being the only way to avert long COVID.1 month ago News Medical
In a recent study published in JAMA Network Open, researchers quantified the association between cigarette smoking and all-cause and cause-specific deaths by sex, ethnicity, and race. Among current smokers, non-daily smoking was most commonly reported among Hispanics (males, 40% and females 33%) and was least commonly reported among Whites (16% for males and females). An RR value of 2.8 was observed for all-cause deaths among current smokers versus never smokers. The relative excess deaths associated with current smoking were usually comparable in males and females, with RR values of 2.7 and 2.9, respectively. Associations between never-smokers and former or current smokers were comparable when stratified by the duration of follow-up.1 month ago News Medical
Download a copy todayStudy: Reduction of SARS-CoV-2 viral load in exhaled air by antiseptic chewing gum: a pilot trial. The viral load was measured before and after using an antiseptic chewing gum at different time points. Exhaled air samples were collected at different time intervals including before and after 15 minutes of using antiseptic chewing gum. The mean difference in Ct values before chewing the antiviral chewing gum and 15 minutes after chewing the gum was 3.8. After two hours of chewing the antiseptic chewing gum, the viral load dropped between 84% and 93%.1 month ago News Medical
In a recent study posted to the medRxiv* preprint server, University of Arizona researchers assessed the relationship between antibody responses and analgesic usage after coronavirus disease 2019 (COVID-19) vaccination. Study: No evidence that analgesic use after COVID-19 vaccination negatively impacts antibody responses. The team assessed the survey data related to analgesic usage between 15 March 2021 and 22 March 2022. However, the most reasonable interpretation for the increase in antibody levels was that inflammation and adverse events were related to antibody increase instead of analgesic usage. Overall, the study findings showed no evidence that the use of analgesics following COVID-19 vaccination had a negative effect on antibody responses.1 month ago News Medical